Keith gets violent with Dan after learning that Dan paid Jules to fall in love with Keith. Anna turns Felix in to the school authorities after learning that he was the one who vandalized Peyton's locker. Lucas and Brooke discuss Brooke's possible move. Meanwhile, Nathan chances Haley in the hope of bringing her home. Brooke decides to move in with Karen.
Catwoman's cat, Isis, steals a cursed gem that causes Ace to run into a string of bad luck.
The team's plan to con an auction house with a comic book forgery goes awry when corrupt copper, Sam Phillips (played by Fay Ripley), decides she wants in on the play.
Jim, certain he will win the annual hot dog eating contest, is humiliated when instead he loses to a petit woman (Suzy Nakamura), and his problems are further compounded when Andy decides to date the female champion.
House and his team battle to diagnose a pregnant patient's life-threatening illness, prompting her to make the most emotional decision of her life, and Vogler is determined to fire House.
Luke helps turn an old house into a museum. Lorelai says too much during an interview about the inn. Rory, Paris and Lane have boyfriend trouble.
Vic and Monica stake a deal with the DEA to shut down Mitchell's tar heroin operation. When the bust comes up empty, Vic's suspicions of Shane grow, until Shane proves himself by coming up with a key piece of evidence that reveals a large stash of tar being stored at a local church. Meanwhile, Dutch and Claudette's friendship continues to feel strain as they try to tie a young woman's murder to a suspected serial killer. Plus, Julien takes a stand against Monica's policy, then goes to David for support when she suggests he consider transferring out of Farmington.
Turk won't open up at couples therapy. Elliot refuses Dr. Cox's romantic advice, when a very attractive man saunters into the hospital. J.D. learns a lesson in humanity from a dying old woman. The Janitor accidently lets a bunch of rats run around Sacred Heart.
While helping her classmate Mandy search for her missing Jack Russell terrier, Veronica stumbles onto a bigger mystery, which affects pets all over Neptune. Meanwhile, tensions mount in the Echolls family as Trina tries to convince the now-retired Aaron to take a part in her new boyfriend's independent movie. Later, Weevil is arrested for breaking into the Kane residence and taking something from Lilly's room.
Curtis brings in a suspect who has critical information about Marwan's next strike. Michelle orders Curtis to use harsh methods to interrogate the suspect, but things get complicated when Marwan sends a lawyer to defend his rights. Logan's advisors begin to worry as he continues to exhibit fear in the face of the ongoing terrorist threat.
Telly Monster tells Gordon that he feels miserable because in order to go on Oscar’s Annual Grouch Picnic and Field Day, he has to learn the Official Grouch Cheer and he’s the only one who can’t do it right. Gordon talks to Oscar and convinces him to let Telly try learning to do it right. Telly is so discouraged at this point that he keeps saying that he can’t do the cheer. Gordon motivates Telly by practicing the cheer with him and by telling him that he can do it! Through Gordon’s encouragement, constant practice, and believing in himself, Telly finally learns to do the cheer! Telly shows Oscar that he can do the cheer beautifully, and boards the bus to go on the field trip with all the other Grouchketeers!
Streaky programs Dogbot to help Krypto so he can have more time with Kevin.
On the morning of his Julliard audition in New York, Ephram makes plans to meet up with Madison (guest star Sarah Lancaster) for coffee where he finds out that she was pregnant with his child. This devastating revelation causes Ephram to make decisions that will alter the course of his life. Amy tries to figure out what this will do to her and Emphram's relationship. Meanwhile, Dr. Abbott counsels a man (guest star Chris Penn) whose son may die as a result of a hunting accident.
Horatio's life is changed forever when he learns important information about his deceased brother. Horatio must now figure out what to do with this information about his brother, Raymond, and whether or not to tell Yelina. Meanwhile, the team investigates when a woman is murdered at a crowded bar after she's approached by a female employee of a service that helps men pick-up women. Also, when Delko loses his badge after some reckless behavior and it's used in a crime, he must locate the badge before it's used again.
After Amy spends an hour chatting with Ray while he is trying to watch the basketball game, he tells Robert that she talks to much, which of course, Robert repeats to Amy, leading to a confrontation between Ray and "Lady Chatterly."
Rose tries to help the brothers sort out their feelings, when Charlie and Alan take their personal frustrations out on each other.
In an attempt to lure the sisters out of the manor, Zankou sends his underlings to attack Leo, in order for him to search the house for the Nexus and release the Shadow, the ultimate power. Meanwhile, in order to protect his parents Wyatt magically shrinks them and traps them inside a dollhouse, and Phoebe is left in charge of the newspaper.
Lynette learns that no good deed goes unpunished when she momentarily befriends the mean Mrs. McClusky. Susan's mother decides to try and jump start her and her daughter's love lives. Andrew talks to a priest about his feelings, and tells him of his shocking plans for his mother, Bree. Gabrielle has her credit card declined in an upscale restaurant, and Carlos sends Gabrielle a big message about what will happen if she leaves him.
Gob hides George Sr. while the model home's plumbing is checked; George Michael helps Ann protest Maeby's new movie; Tobias takes a liking to Kitty after Michael asks him to keep an eye on her.
Through Professor Frink's future machine, Bart and Lisa see their lives in the year 2013, where Bart steals Lisa's chances at going to an Ivy League school in order to impress a skater girl named Jenda while Homer (now separated from Marge and living in an underwater apartment) fights Krusty the Clown after Marge begins dating him.