After Shelbyville accuses Springfield of being hicks, Marge convinces the townspeople to fund a Frank Gehry-designed concert hall, which is then converted to a prison when the concert hall goes bankrupt on opening night. Meanwhile, Bart and Lisa investigate Snowball II's recent weight gain.
Doc Cochran advises Dan and Johnny how to help Swearengen's recovery. Thriving business at a new brothel leads to a startling discovery by Tolliver. Merrick gets a scoop from Yankton about gold claims. Bullock's badge comes in handy for Commissioner Jarry.
The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile Meredith puts her career on the line to save a newborn in the hospital nursery, and the other interns learn that it takes more than just medical knowledge to be good at their jobs.
When Francis and Piama choose to celebrate Francis' 21st birthday at the house, Hal is reminded of a promise he made to his son as a young child, involving a motorcycle trip that Lois quickly forbids. Hal and Francis have no choice but to sneak off for their wild adventure, leaving their women behind. Meanwhile Malcolm, Dewey and Reese are held captive in their own home by a bully.
Bam builds a bayou in front of Don Vito's trailer. Vito falls in and gets into one of his usual angry fits. In doing so, he claims that bayous only exist in Louisiana, so Bam decides to go there. Phil decides to stay home because he figures that it would be more fun than going to Louisiana, so it becomes a competition between Phil and Bam to see who can have the most fun.
A teenage girl gets a fashion makeover in "Pimp My Sister." The Surreal Life gang gets sent on a mission to destroy an enchanted ring. Debbie Does Dallas gets re-told with the world's cheapest puppets in "Exhausted Budget Theater." Geeks and nerds collide when a science fiction convention erupts into war.
Randy makes an odd request of Sue. He asks her for some help with woman he is about to meet there is one problem in the correspondence Randy and his date have shared over the computer she forgot to tell Randy she was deaf. Sue now has to accompany Randy on his date to help him with the sign language.
When Audrey and Walter go out of town for spring break they leave Drake, Josh, and Megan at home by themselves. When they are at the Premiere they overhear a couple saying that they don't have a place to stay. Drake and Josh take advantage of this opportunity and say that their vacant house is a hotel. Meanwhile, Megan is attempting to get Drake and Josh to treat her like a guest.
Leonardo and Usagi arrive in the Battle Nexus hoping for a way to reunite the four turtles and their master. But they find the Battle Nexus under the control of the evil Ultimate Drako and Master Splinter is his prisoner.
After the "Atlantis" ship disappeared, Optimus Prime and Megatron head to the moon where it's hiding while Vector Prime and the kids locate the Omega Lock. Will the Autobots prevent the Decepticons from getting the Omega Lock? And what does a side-changing Transformer named Sideways have planned?
The Doctor takes Rose on her first voyage through time: to the year five billion, when the Sun is about to expand and swallow the Earth. She is cautious and soon starts to question her reasons for joining The Doctor. But amongst the powerful alien races gathering to watch on Platform One, a murderer is at work. Who is controlling the mysterious and deadly metal spiders?
The Mystery Kids head for a NASCAR-like championship race where mayhem is taking place on the racetracks.
Officially a full-time teacher, C.J. is overjoyed to finally get access to the teachers' lounge. But he soon finds himself being bullied out of the room by the school's overzealous Home Ec instructor. Rory wants to impress a girl, so Bridget and Kerry take it upon themselves to give him a full-fledged makeover.
When Billy and Mandy's school is preparing for a big game, Mindy entrusts the care of the school's mascot, Fluffy Cat, to Billy, to protect him from being kidnapped by the rival team, the Booty Heads. At Billy's house, Fluffy Cat is a disaster, so Billy's mom throws him into the basement, where the cat gets inside Grim's trunk, absorbing its powers. A giant Fluffy Cat appears just before the game wreaking havoc.
As Billy is tired of all the rules in his house, he cannot resist the urge to try his father's new motorcycle. The motorcycle breaks down, and Billy asks Grim to repair it. Grim's scythe turns the motorcycle into a wild, supernatural vehicle, which transforms Billy's parents and everyone around it into undead creatures and motorized monsters. Mandy makes Billy tell the truth about breaking the motorcycle in the first place, at which point his parents and everyone else return to normal.
Kibre tries a celebrity basketball star accused of raping and murdering his mistress. However, she runs into trouble when the star's wife has a slip of the tongue on the stand.
Experiment 133: PJ Lilo's always getting blamed for Mertle's pranks, so she figures it's high-time to pull a few pranks of her own, and what better prank-ee than the mean old substitute hula teacher?
A teenage slacker is given the ability to turn into the American Dragon and defend all mythical creatures that secretly reside in the human world.